Analysis and Treatment of Multiple Severe Venous Vascular Malformation Syndrome Combined with Coagulopathy

According to a new international classification of vascular lesions, venous vascular malformation has become the most common type of congenital vascular malformation. A characteristic of this disease is its life‐long progressive development, which is the main cause of harm to health and is different from hemangioma. Severe hemangioma with thrombocytopenia (Kasabach–Merritt syndrome)[1] is often encountered in children, especially in infants younger than 1 year old. Coagulation abnormalities in Kasabach–Merritt syndrome are mainly caused by increased platelet destruction. Whereas, severe venous malformation‐associated coagulopathy is attributed to the depletion of coagulation substances and extensive intravenous coagulation, and it occurs in adults. In principle, surgery is required; however, there is no opportunity for surgery to treat severe venous malformation which is the main difference from Kasabach–Merritt syndrome. It may be incurable at present. Here, we report a series of clinically rare multiple severe systemic venous vascular malformation syndrome cases.